As mentioned earlier I am using zBrush and I am still at the beginning of the learning curve. Lessons learned: it is much easier with a Wacom tablet, and Layers are an awesome way to store and mix shapes in zBrush. Challenges still unresolved: When starting from a rest-open shape (like the upper left skull in the strip below), remodeling the mouth to a narrow "O" is really a pain as the geometry gets really stretched.
(For those experts in zBrush out there, I am sculpting in Dynamesh, but the Layer feature prevents me from re-meshing... leaving me in a quandary... either not using layer or not re-meshing)
|Celso Mouth Set strip|